F1063-0967

Names

[ Name ]:
F1063-0967

[Synonym ]:
Benzoic acid, 2-hydroxy-4-[[6-[(5Z)-5-[(4-methylphenyl)methylene]-4-oxo-2-thioxo-3-thiazolidinyl]-1-oxohexyl]amino]-
MFCD04423481
2-Hydroxy-4-({6-[(5Z)-5-(4-methylbenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]hexanoyl}amino)benzoic acid
F1063-0967

Biological Activity

[Description]:

F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

Research Areas >> Cancer

[Target]

IC50: 11.62 μM (DUSP26)[1]

[In Vitro]

F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM. At concentration above 0.1 μM, F1063-0967 remarkably induces IMR32 cell apoptosis. F1063-0967 induces apoptosis in IMR-32 cell line with an IC50 value of 4.13 μM. F1063-0967 has no effect on HL7702 cell line, and little inhibition effect on SH-SY5Y cell line[1].

[Cell Assay]

The IMR-32 cells are plated in 96-well plates with 1×103 cells per well. After the cells are allowed to settle for 24 h, F1063-0967 (0, 10, 1, and 0.1 μM) is added. An MTTassay is performed. For cell lines HL7702 and SH-SY5Y, the cells are allowed to settle for 24 h, F1063-0967 (10 μM) is added, then MTT assays are carried out after 72 h[1].

[References]

[1]. Ren JX, et al. Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based on pharmacophore and molecular docking. Biomed Pharmacother. 2017 May;89:376-385.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₄H₂₄N₂O₅S₂

[ Molecular Weight ]:
484.588

[ Exact Mass ]:
484.112671

[ LogP ]:
5.03

[ Index of Refraction ]:
1.704

[ Storage condition ]:
2-8℃

Related Compounds

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