VU0152099

Names

[ Name ]:
VU0152099

[Synonym ]:
3-Amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-(1,3-benzodioxol-5-ylmethyl)-4,6-dimethyl-
VU0152099

Biological Activity

[Description]:

VU0152099 is a potent, selective, CNS-penetrant positive allosteric modulator of M4 mAChR with EC50 of 403 nM; shows no agonist activity but potentiates responses of M(4) to acetylcholine, and is devoid of activity at other mAChR subtypes or at a panel of other GPCRs; reverses amphetamine-induced hyperlocomotion in rats.

[References]

References 1. Brady AE, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53. View Related Products by Target mAChR

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
622.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₇N₃O₃S

[ Molecular Weight ]:
355.411

[ Flash Point ]:
330.5±31.5 °C

[ Exact Mass ]:
355.099060

[ LogP ]:
4.32

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.708