1-Methyl-2-nitrosobenzene
Names
[ CAS No. ]:
611-23-4
[ Name ]:
1-Methyl-2-nitrosobenzene
[Synonym ]:
2-Methyl-1-nitrosobenzene
o-Nitrosotoluene
1-Methyl-2-nitrosobenzene
Benzene,1-methyl-2-nitroso
Benzene, 1-methyl-2-nitroso-
MFCD00002061
2-methyl-nitrosobenzene
TOLUENE,o-NITROSO
2-nitrosotoluene
ortho-nitrosotoluene
o-methyl-nitrosobenzene
EINECS 210-261-4
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
199.9±19.0 °C at 760 mmHg
[ Melting Point ]:
72-75 °C(lit.)
[ Molecular Formula ]:
C7H7NO
[ Molecular Weight ]:
121.137
[ Flash Point ]:
74.7±26.8 °C
[ Exact Mass ]:
121.052765
[ PSA ]:
29.43000
[ LogP ]:
2.47
[ Vapour Pressure ]:
0.5±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.524
[ Storage condition ]:
0-6°C
[ Stability ]:
Stable. Incompatible with oxidizing agents.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XT3400000
- CHEMICAL NAME :
- Toluene, o-nitroso-
- CAS REGISTRY NUMBER :
- 611-23-4
- BEILSTEIN REFERENCE NO. :
- 1927295
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C7-H7-N-O
- MOLECULAR WEIGHT :
- 121.15
- WISWESSER LINE NOTATION :
- ONR B1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 103 gm/kg/73W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 1 umol/plate
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 25,618,1987
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
26-36
[ RIDADR ]:
UN1759
[ WGK Germany ]:
3
[ RTECS ]:
XT3400000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
Synthetic Route
Articles
Arch. Biochem. Biophys. 436(2) , 265-75, (2005)
The inactivation of cytochrome P450 enzymes by cyclopropylamines has been attributed to a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring l...
Distinct mechanisms of oxidative DNA damage by two metabolites of carcinogenic o-toluidine.Arch. Biochem. Biophys. 372(1) , 97-106, (1999)
Mechanisms of DNA damage by metabolites of carcinogenic o-toluidine in the presence of metals were investigated by the DNA sequencing technique using (32)P-labeled human DNA fragments. 4-Amino-3-methy...
Comparative carcinogenicity of o-toluidine hydrochloride and o-nitrosotoluene in F-344 rats.Cancer Lett. 16(1) , 103-8, (1982)
o-Toluidine hydrochloride and one of its metabolites, o-nitrosotoluene, were administered in the diet (0.028 mol/kg diet) to 2 groups of 30 male F-344 rats for 72 weeks. o-Nitrosotoluene induced signi...