FC131

Names

[ Name ]:
FC131

[Synonym ]:
Cyclo[3-(2-naphthalenyl)-L-alanylglycyl-D-tyrosyl-L-arginyl-L-arginyl]
Cyclo[3-(2-naphthyl)-L-alanylglycyl-D-tyrosyl-L-arginyl-L-arginyl]
Cyclo[3-(2-naphthyl)-D-alanylglycyl-D-tyrosyl-N-(diaminomethylene)-L-ornithyl-N-(diaminomethylene)-L-ornithyl]
Cyclo[3-(2-naphthalenyl)-D-alanylglycyl-D-tyrosyl-N-(diaminomethylene)-L-ornithyl-N-(diaminomethylene)-L-ornithyl]
1',2-{[(2S,5S,8S,14R)-14-(4-hydroxybenzyl)-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecane-2,5-diyl]dipropane-3,1-diyl}diguanidine (non-preferred name)

Biological Activity

[Description]:

FC131 TFA 是一种 CXCR4 拮抗剂，抑制 [125I]-SDF-1 与 CXCR4 结合，IC50 值为 4.5 nM。FC131 TFA 具有抗 HIV 的活性。

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> GPCR/G Protein >> CXCR

Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

125I-SDF-CXCR4:4.5 nM (IC50)

HIV

[References]

[1]. Tamamura H, et al. Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem. 2005 Jan 27;48(2):380-91.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₃₆H₄₇N₁₁O₆

[ Molecular Weight ]:
729.828

[ Exact Mass ]:
729.371094

[ PSA ]:
289.53000

[ LogP ]:
-0.81

[ Index of Refraction ]:
1.696

Related Compounds

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