m-PEG4-azide

Names

[ Name ]:
m-PEG4-azide

[Synonym ]:
AmbotzPEG1690
Me(OCH2CH2)4N3
O-(2-Azidoethyl)-O inverted exclamation marka-methyl-triethylene glycol
MeO-PEG4-Azide
1-azido-11-methoxy-3,6,9-trioxaundecane
1-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}-2-methoxyethane
m-dPEG.(TM).4-azide
13-Azido-2,5,8,11-tetraoxatridecane

Biological Activity

[Description]:

m-PEG4-azide (13-Azido-2,5,8,11-tetraoxatridecane) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Belen Begines, et al. Synthesis of Reduction Sensitive Comb-Like Polyurethanes Using Click Chemistry. Journal of Polymer Science Part A: Polymer Chemistry, 2016, 54(24), 3888-3900.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₉N₃O₄

[ Molecular Weight ]:
233.26500

[ Exact Mass ]:
233.13800

[ PSA ]:
86.67000

[ LogP ]:
0.44566

[ Index of Refraction ]:
1.4500 to 1.4540

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
29299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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