(2S)-2-(Dibenzylamino)-1-propanol

Names

[ Name ]:
(2S)-2-(Dibenzylamino)-1-propanol

[Synonym ]:
(S)-2-(N,N-Dibenzylamino)-1-propanol
2-(N,N-dibenzyl)amino-1-propanol
(2S)-2-(Dibenzylamino)-1-propanol
(2S)-2-(dibenzylamino)propan-1-ol
(S)-(+)-2-(Dibenzylamino)-1-propanol
(S)-N,N-dibenzyl-2-amino-1-propanol
S-2-(N,N-dibenzylamino)propanol
(S)-2-(Dibenzylamino)propan-1-ol
N,N-dibenzyl-(S)-2-amino-1-propanol
1-Propanol, 2-[bis(phenylmethyl)amino]-, (2S)-
1-Propanol, 2-(dibenzylamino)-, (S)-
MFCD00191985

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
374.2±22.0 °C at 760 mmHg

[ Melting Point ]:
46-48ºC(lit.)

[ Molecular Formula ]:
C₁₇H₂₁NO

[ Molecular Weight ]:
255.355

[ Flash Point ]:
140.2±18.9 °C

[ Exact Mass ]:
255.162308

[ PSA ]:
23.47000

[ LogP ]:
4.08

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.583

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Preparation of Aminoalkyl Chlorohydrin Hydrochlorides: Key Building Blocks for Hydroxyethylamine-Based HIV Protease Inhibitors.

J. Org. Chem. 61 , 3635, (1996)

Enantiomerically pure N,N-dibenzyl-alpha-amino aldehydes reacted with (chloromethyl)lithium, generated in situ from bromochloromethane and lithium metal, to give predominantly erythro aminoalkyl epoxi...

Stereoselective Synthesis of HIV-1 Protease Inhibitor, DMP 323.

J. Org. Chem. 61 , 444, (1996)

DMP 323, a potent HIV-1 protease inhibitor, has been synthesized by an efficient stereoselective process, amenable to large scale preparations. The core C(2) symmetric diol was synthesized by a stereo...

Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.

J. Med. Chem. 39 , 3514, (1996)

High-resolution X-ray structures of the complexes of HIV-1 protease (HIV-1PR) with peptidomimetic inhibitors reveal the presence of a structural water molecule which is hydrogen bonded to both the mob...