Pifithrin-β
Names
[ CAS No. ]:
60477-34-1
[ Name ]:
Pifithrin-β
[Synonym ]:
Pifithrin-Beta
UNII-45I8QO7K37
Pifithrin-β
Biological Activity
[Description]:
Pifithrin-β is a potent p53 inhibitor with an IC50 of 23 μM.
[Related Catalog]:
[Target]
IC50: 23 μM (p53)[1]
[In Vitro]
Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3].
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C16H16N2S
[ Molecular Weight ]:
268.37700
[ Exact Mass ]:
268.10300
[ PSA ]:
45.54000
[ LogP ]:
4.25000
[ Storage condition ]:
2-8℃