TAMARIXETIN

Names

[ CAS No. ]:
603-61-2

[ Name ]:
TAMARIXETIN

[Synonym ]:
Flavone, 3,3',5,7-tetrahydroxy-4'-methoxy-
Quercetin 4'-methyl ether
Quercetin-4'-methylether
3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
4'-O-Methyl quercetin
4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-
TAMARIXETIN
4'-Methoxyquercetin
3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
Flavone, 4'-methoxy-3,3',5,7-tetrahydroxy-
Quercetin-4'-methyl ether
Tamaraxetin
4'-Methoxy-3,3',5,7-tetrahydroxy-flavone

Biological Activity

[Description]:

Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin, with anti-oxidative and anti-inflammatory effects. Tamarixetin protects against cardiac hypertrophy[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Fan C, et al. Tamarixetin protects against cardiac hypertrophy via inhibiting NFAT and AKT pathway. J Mol Histol. 2019 Aug;50(4):343-354.

[2]. Park HJ, et al. Tamarixetin Exhibits Anti-inflammatory Activity and Prevents Bacterial Sepsis by Increasing IL-10 Production. J Nat Prod. 2018 Jun 22;81(6):1435-1443.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
601.8±55.0 °C at 760 mmHg

[ Melting Point ]:
265-268ºC

[ Molecular Formula ]:
C₁₆H₁₂O₇

[ Molecular Weight ]:
316.262

[ Flash Point ]:
228.8±25.0 °C

[ Exact Mass ]:
316.058289

[ PSA ]:
120.36000

[ LogP ]:
2.42

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.741

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK8745000

CHEMICAL NAME :: Flavone, 4'-methoxy-3,3',5,7-tetrahydroxy-

CAS REGISTRY NUMBER :: 603-61-2

BEILSTEIN REFERENCE NO. :: 0324993

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-O7

MOLECULAR WEIGHT :: 316.28

WISWESSER LINE NOTATION :: T66 BO EVJ CR CQ DO1& DQ GQ IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 166 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 54,297,1978

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
22

[ Safety Phrases ]:
22-45