Desacetyl Bisacodyl

Names

[ CAS No. ]:
603-41-8

[ Name ]:
Desacetyl Bisacodyl

[Synonym ]:
4,4'-pyridin-2-ylmethanediyl-bis-phenol
EINECS 210-039-7
Deacetylbisocodyl
DDPM
La-96
deacetylbisacodyl
Dihydroxydiphenyl-pyridyl methane

Biological Activity

[Description]:

Desacetyl bisacodyl is the active metabolite of the laxative bisacodyl. Desacetyl bisacodyl induces epithelial Cl(-) secretion in rat colon and rectum. Desacetyl bisacodyl evokes several effects at the colon or rectum, including increased mucus and chloride secretion[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Fujita T, et, al. Desacetyl bisacodyl-induced epithelial Cl(-) secretion in rat colon and rectum. Biomed Res. 2016;37(1):13-20.

Chemical & Physical Properties

[ Density]:
1.244g/cm3

[ Boiling Point ]:
462.1ºC at 760 mmHg

[ Melting Point ]:
>200ºC (dec.)

[ Molecular Formula ]:
C₁₈H₁₅NO₂

[ Molecular Weight ]:
277.32

[ Flash Point ]:
233.3ºC

[ Exact Mass ]:
277.11000

[ PSA ]:
53.35000

[ LogP ]:
3.67300

[ Index of Refraction ]:
1.655

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM8730000

CHEMICAL NAME :: Phenol, 4,4'-(2-pyridylmethylene)di-

CAS REGISTRY NUMBER :: 603-41-8

BEILSTEIN REFERENCE NO. :: 0212040

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H15-N-O2

MOLECULAR WEIGHT :: 277.34

WISWESSER LINE NOTATION :: T6NJ BYR DQ&R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8550 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950- Volume(issue)/page/year: 28,258,1977

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Related Compounds

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