Glabrol

Names

[ Name ]:
Glabrol

Biological Activity

[Description]:

Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity[1].

[Target]

ratACAT:24.6 μM (IC50)

[In Vitro]

Glabrol (Compound 1) decreases cholesteryl ester formation with an IC50 value of 26.0 μM in HepG2 cells[1].

[References]

[1]. Choi JH, et al. Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots. J Ethnopharmacol. 2007 Apr 4;110(3):563-6.

Chemical & Physical Properties

[ Density]:
1.166g/cm3

[ Boiling Point ]:
600ºC at 760 mmHg

[ Melting Point ]:
121-123 C

[ Molecular Formula ]:
C₂₅H₂₈O₄

[ Molecular Weight ]:
392.48700

[ Flash Point ]:
204.3ºC

[ Exact Mass ]:
392.19900

[ PSA ]:
66.76000

[ LogP ]:
5.82170

[ Index of Refraction ]:
1.599