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Y-9738

Names

[ CAS No. ]:
59399-41-6

[ Name ]:
Y-9738

[Synonym ]:
[2-(4-chlorophenyl)-3H-imidazol-4-yl]methanol
ethyl-2-(4-chlorophenyl)-5-ethoxy-4-oxazole acetate
[2-(4-chloro-phenyl)-5-ethoxy-oxazol-4-yl]-acetic acid ethyl ester
ethyl 2-p-chlorophenyl-5-ethoxy-4-oxazoleacetate
Y-9738

Biological Activity

[Description]:

Y-9738 is a hypolipidemic agent.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cardiovascular Disease

[In Vivo]

Y-9738 is a hypolipidemic agent. At 100 mg/kg Y-9738 lowers the cholesterol level by 36% and clearly diminishes the intensity of the β-lipoprotein band with a tendency for the α-lipoprotein band to be intensified. Y-9738 causes a dose-dependent decrease in serum cholesterol, triglyceride and heparin-precipitable β-lipoprotein cholesterol. Furthermore, Y-9738 reduces the intensity of the β-lipoprotein band shown by electrophoresis, and increases that of the α-lipoprotein band[1].

[Animal admin]

Male Sprague-Dawley rats are used in this work. Rats (140 to 180 g) are fed a high cholesterol diet for 10 days. This diet contains 1% cholesterol, 0.2% sodium cholate and 5% olive oil. Y-9738 is orally administered to the animals once a day throughout the experimental period. All animals are starved overnight (about 20 h) after the last treatment and sacrificed by carotid incision. Blood and liver are collected for lipid analysis[1].

[References]

[1]. Kobayakawa T, et al. Experimental hyper-beta-lipoproteinemia and its amelioration by a novel hypolipidemic agent. Atherosclerosis. 1978 Jul;30(3):219-25.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.226g/cm3

[ Boiling Point ]:
416.2ºC at 760 mmHg

[ Molecular Formula ]:
C15H16ClNO4

[ Molecular Weight ]:
309.74500

[ Flash Point ]:
205.5ºC

[ Exact Mass ]:
309.07700

[ PSA ]:
61.56000

[ LogP ]:
3.49930

[ Index of Refraction ]:
1.53

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Related Compounds