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GL-1196

Names

[ CAS No. ]:
591242-70-5

[ Name ]:
GL-1196

[Synonym ]:
Phenol, 2-[[(4-chlorophenyl)(1,1-dioxido-1,2-benzisothiazol-3-yl)amino]methyl]-
2-{[(4-Chlorophenyl)(1,1-dioxido-1,2-benzothiazol-3-yl)amino]methyl}phenol
MFCD04084648

Biological Activity

[Description]:

GL-1196 is a PAK4 inhibitor that effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclinD1 pathway and CDK4/6 expression; prominently inhibits the invasion of human gastric cancer cells in parallel with blockage of the PAK4/LIMK1/cofilin pathway; also inhibits the formation of filopodia and induced cell elongation in SGC7901 and BGC823 cells.

[References]

References 1. Zhang J, et al. Int J Mol Sci. 2016 Apr 11;17(4):470. View Related Products by Target p21-activated Kinase (PAK)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
626.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H15ClN2O3S

[ Molecular Weight ]:
398.863

[ Flash Point ]:
332.6±34.3 °C

[ Exact Mass ]:
398.049194

[ LogP ]:
4.01

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.679

Related Compounds

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