3-Hydroxy-3-(2H3)methylpentanedioic acid

Names

[ CAS No. ]:
59060-36-5

[ Name ]:
3-Hydroxy-3-(2H3)methylpentanedioic acid

[Synonym ]:
3-hydroxy-3-<2H3>methylglutaric acid
3-Hydroxy-3-(H)methylpentanedioic acid
3-hydroxy-3-<methyl-2H3>pentane-1,5-dioic acid
3-Hydroxy-3-trideuteromethylglutarsaeure
3-Hydroxy-3-<3.4.5-trimethoxy-phenyl>-3-<3.4-methylendioxy-phenyl>-propionsaeure-ethylester
Pentanedioic acid, 3-hydroxy-3-(methyl-d)-

Biological Activity

[Description]:

Meglutol-d3 is the deuterium labeled Meglutol[1]. Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)
Signaling Pathways >> Autophagy >> Autophagy

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
354.3±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C6H7D3O5

[ Molecular Weight ]:
165.159

[ Flash Point ]:
182.2±21.6 °C

[ Exact Mass ]:
165.071655

[ PSA ]:
94.83000

[ LogP ]:
-2.33

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.515

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds