Sinefungin
Names
[ CAS No. ]:
58944-73-3
[ Name ]:
Sinefungin
[Synonym ]:
(2S,5S)-2,5-Diamino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]hexanoic acid (non-preferred name)
Sinefungin
D-Glycero-α-L-talo-Decofuranuronic acid, 6,9-diamino-1- (6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-
6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-D-glycero-a-L-talo-decofuranuronic Acid
Antibiotic 32232RP
(5S)-5-Amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-L-norleucine
(5S)-5-Amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]-L-norleucine
UNII:W2U467CIIL
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.9±0.1 g/cm3
[ Boiling Point ]:
783.2±70.0 °C at 760 mmHg
[ Molecular Formula ]:
C15H23N7O5
[ Molecular Weight ]:
381.39
[ Flash Point ]:
427.5±35.7 °C
[ Exact Mass ]:
381.176056
[ PSA ]:
208.65000
[ LogP ]:
-1.33
[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C
[ Index of Refraction ]:
1.832
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HE3140000
- CHEMICAL NAME :
- D-glycero-alpha-L-talo-Decofuranuronic acid, 6,9-diamino-1-(6-amino-9H-purin-9-yl)- 1,5,6,7,8,9-hexadeoxy-
- CAS REGISTRY NUMBER :
- 58944-73-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C15-H23-N7-O5
- MOLECULAR WEIGHT :
- 381.45
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,298,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 185 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 26,463,1973
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S36
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
HE3140000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Br. J. Pharmacol. 172(3) , 857-68, (2015)
AT1 receptor blockers (ARBs) represent an approach for treating metabolic syndrome due to their potency in reducing hypertension, body weight and onset of type 2 diabetes. The mechanism underlying ARB...
DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.Mol. Cancer Ther. 8 , 1579-1588, (2009)
DNA methylation, histone modifications, and nucleosomal occupancy collaborate to cause silencing of tumor-related genes in cancer. The development of drugs that target these processes is therefore imp...
Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.FEBS J. 277(9) , 2096-108, (2010)
The protein arginine methyltransferase (PRMT) family of enzymes catalyzes the transfer of methyl groups from S-adenosylmethionine to the guanidino nitrogen atom of peptidylarginine to form monomethyla...