aspidin BB

Names

[ CAS No. ]:
584-28-1

[ Name ]:
aspidin BB

[Synonym ]:
Aspidin VV
Aspidin
aspidin-BB

Biological Activity

[Description]:

Aspidin BB is a phloroglucinol derivative, which can be isolated from the aerial part of Dryopteris championii. Aspidin BB has anticancer activity. Aspidin BB induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> Caspase

[Target]

Bcl-2

Bax

Caspase-3

[In Vitro]

Aspidin BB (0-100 μM, 24-72 h) 以剂量和时间依赖性方式显着抑制 HO-8910 细胞增殖。处理 72、48 和 24 小时后IC50值分别为 15.02、25.79 和 68.81 μM[1]。 Aspidin BB 抑制 Bcl-2 表达并增强 Bax 表达以破坏线粒体外膜，然后引起细胞色素 c 释放导致效应 caspase-3 激活，并进一步切割细胞核中的聚 ADP-核糖聚合酶 (PARP)，最终诱导细胞凋亡[1]。 Aspidin BB 通过上调 pRb、E2F1、CDK2、细胞周期蛋白 E 和细胞周期蛋白 A 蛋白在 HO-8910 细胞中引起 S 期阻滞[1]。

[References]

[1]. Sun Y, et al. Aspidin BB, a phloroglucinol derivative, induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells. Chem Biol Interact. 2013 Jul 5;204(2):88-97.

[2]. Chen NH, et al. Drychampones A-C: Three Meroterpenoids from Dryopteris championii. J Org Chem. 2016 Oct 7;81(19):9443-9448.

Chemical & Physical Properties

[ Density]:
1.285g/cm3

[ Boiling Point ]:
704.9ºC at 760mmHg

[ Molecular Formula ]:
C₂₅H₃₂O₈

[ Molecular Weight ]:
460.51700

[ Flash Point ]:
236.6ºC

[ Exact Mass ]:
460.21000

[ PSA ]:
141.36000

[ LogP ]:
4.54240

[ Index of Refraction ]:
1.594

Related Compounds

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