2,7-Dihydroxynaphthalene

Names

[ CAS No. ]:
582-17-2

[ Name ]:
2,7-Dihydroxynaphthalene

[Synonym ]:
2,7-dihydroxy naphthalene
2,7-Dihydroxynaphthalene
2,7-dihydroxylnaphthalene
EINECS 209-478-7
naphthalene-2,7-diol
2,7-Naphthalenediol
naphthalenediol-2,7
2,7-Dihydroxy
2,5-DIMETHYLBENZOTRIFLUORIDE
2,7-Naphthelendiol
2,7-Naphtalenediol
MFCD00004085
2,7-DON
2,7-NAPTHTALENEDIOL

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
375.4±15.0 °C at 760 mmHg

[ Melting Point ]:
185-190 °C(lit.)

[ Molecular Formula ]:
C₁₀H₈O₂

[ Molecular Weight ]:
160.169

[ Flash Point ]:
193.5±15.0 °C

[ Exact Mass ]:
160.052429

[ PSA ]:
40.46000

[ LogP ]:
1.98

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.726

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ4780000

CHEMICAL NAME :: 2,7-Naphthalenediol

CAS REGISTRY NUMBER :: 582-17-2

BEILSTEIN REFERENCE NO. :: 2042383

LAST UPDATED :: 199710

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H8-O2

MOLECULAR WEIGHT :: 160.18

WISWESSER LINE NOTATION :: L66J CQ IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 13,381,1978

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
QJ4780000

[ HS Code ]:
29072900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2907299090

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Articles

Selective antiproliferative activity of hydroxynaphthyl-beta-D-xylosides.

J. Med. Chem. 49 , 1932-8, (2006)

The antiproliferative activity of the 14 isomeric monoxylosylated dihydroxynaphthalenes has been tested in vitro toward normal HFL-1 and 3T3 A31 cells as well as transformed T24 and 3T3 SV40 cells. Th...

Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities.

Bioorg. Med. Chem. 16 , 8117-26, (2008)

NphB is a soluble prenyltransferase from Streptomyces sp. strain CL190 that attaches a geranyl group to a 1,3,6,8-tetrahydroxynaphthalene-derived polyketide during the biosynthesis of anti-oxidant nap...

J. Chem. Soc., Perkin Trans. II , 721, (1993)