DSP Crosslinker

Names

[ Name ]:
DSP Crosslinker

[Synonym ]:
2,5-Pyrrolidinedione, 1,1'-[dithiobis[(1-oxo-3,1-propanediyl)oxy]]bis-
DSP
1,1'-{Disulfanediylbis[(1-oxopropane-3,1-diyl)oxy]}dipyrrolidine-2,5-dione
MFCD00042045
1-((3-((3-((2,5-Dioxo-1-pyrrolidinyl)oxy)-3-oxopropyl)dithio)propanoyl)oxy)-2,5-pyrrolidinedione
Di(N-succinimidyl) 3,3'-dithiodipropionate
dithiobis(succinimidyl propionate)
2,5-Pyrrolidinedione, 1,1'-(dithiobis((1-oxo-3,1-propanediyl)oxy))bis-
1,1'-{Disulfanediylbis[(1-oxo-3,1-propanediyl)oxy]}di(2,5-pyrrolidinedione)
(2,5-dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]propanoate
EINECS 260-931-5

Biological Activity

[Description]:

DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Research Areas >> Inflammation/Immunology

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Zorea J, et al. Probing antibody surface density and analyte antigen incubation time as dominant parameters influencing the antibody-antigen recognition events of a non-faradaic and diffusion-restricted electrochemical immunosensor. Anal Bioanal Chem. 2020 Mar;412(7):1709-1717.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
560.1±60.0 °C at 760 mmHg

[ Melting Point ]:
128-133 °C

[ Molecular Formula ]:
C₁₄H₁₆N₂O₈S₂

[ Molecular Weight ]:
404.415

[ Flash Point ]:
292.6±32.9 °C

[ Exact Mass ]:
404.034790

[ PSA ]:
177.96000

[ LogP ]:
-1.66

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.625

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
chloroform: 50 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2930909090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Electrochemical Impedance Immunosensor Based on Self-Assembled Monolayers for Rapid Detection of Escherichia coli O157:H7 with Signal Amplification Using Lectin.

Sensors (Basel.) 15 , 19212-24, (2015)

Escherichia coli O157:H7 is a predominant foodborne pathogen with severe pathogenicity, leading to increasing attention given to rapid and sensitive detection. Herein, we propose an impedance biosenso...

Targeting delivery of tocopherol and doxorubicin grafted-chitosan polymeric micelles for cancer therapy: In vitro and in vivo evaluation.

Colloids Surf. B Biointerfaces 133 , 254-62, (2015)

In this study, we report the development of a novel, redox-sensitive chitosan-based targeted drug delivery system, containing two drugs. We determined whether the synthesized polymeric micelles (HPTOC...

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

Sci. Signal. 7(354) , rs7, (2014)

E-cadherin-mediated cell-cell adhesion and signaling plays an essential role in development and maintenance of healthy epithelial tissues. Adhesiveness mediated by E-cadherin is conferred by its extra...