Cibenzoline succinate
Names
[ CAS No. ]:
57625-97-5
[ Name ]:
Cibenzoline succinate
[Synonym ]:
2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate (2:1)
Succinic acid,compound with 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole (1:2)
EINECS 260-856-8
Butanedioic acid,compd. with 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole (1:2)
1H-Imidazole,4,5-dihydro-2-(2,2-diphenylcyclopropyl)-,succinate (2:1)
Chemical & Physical Properties
[ Boiling Point ]:
449.2ºC at 760 mmHg
[ Molecular Formula ]:
C40H42N4O4
[ Molecular Weight ]:
642.78600
[ Flash Point ]:
225.5ºC
[ Exact Mass ]:
642.32100
[ PSA ]:
123.38000
[ LogP ]:
5.45320
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NI4804900
- CAS REGISTRY NUMBER :
- 57625-97-5
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C36-H36-N4.C4-H6-O4
- MOLECULAR WEIGHT :
- 642.86
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 300 mg/kg/22W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - muscle weakness
- REFERENCE :
- IEDIEP Internal Medicine. (The Japanese Society of Internal Medicine, 34-3, 3-chome, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.31- 1992- Volume(issue)/page/year: 35,512,1996
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 41500 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 22,4485,1988