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Thromboxane A2

Names

[ CAS No. ]:
57576-52-0

[ Name ]:
Thromboxane A2

Biological Activity

[Description]:

Thromboxane A2 (TXA2) is a prostanoid mediator produced by the metabolism of Arachidonic acid (HY-109590) through the cyclooxygenase pathway. Thromboxane A2 activates the thromboxane-prostanoid (TP) receptors. Thromboxane A2 is a potent vasoconstrictor eicosanoid. Thromboxane A2 (TXA2) leads to potent vasoconstriction by stimulation of smooth muscle cells. Thromboxane A2 acts as s tonic immunoregulator to regulate adaptive immune responses[1][2].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Research Areas >> Inflammation/Immunology

[Target]

Human Endogenous Metabolite

TP


[References]

[1]. Matthew A Sparks, et al. Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. Hypertension. 2013 Jan;61(1):166-73.  

[2]. Federica Moalli, et al. Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions. J Exp Med. 2014 Dec 15;211(13):2507-17.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H32O5

[ Molecular Weight ]:
352.46500

[ Exact Mass ]:
352.22500

[ PSA ]:
75.99000

[ LogP ]:
3.81500


Related Compounds

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