1,6-Dihydroxynaphthalene

Names

[ CAS No. ]:
575-44-0

[ Name ]:
1,6-Dihydroxynaphthalene

[Synonym ]:
1,6-Dihydroxy naphthalene
1,6-Dihydroxynaphtalene
4,7-dihydroxynaphthalene
2,5-DIHYDROXYNAPHTHALENE
1,6-dihydroxy-naphthalene
EINECS 209-386-7
6-Hydroxy-1-naphthol
1,6-Naphthalenediol
1,6-Dihydroxynaphthalene
1.6-Dihydroxynaphthalene
2,5-Naphthalenediol
1,6-NAPTHTALENEDIOL
naphthalene-1,6-diol
MFCD00003981

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
375.4±15.0 °C at 760 mmHg

[ Melting Point ]:
130-133 °C(lit.)

[ Molecular Formula ]:
C₁₀H₈O₂

[ Molecular Weight ]:
160.169

[ Flash Point ]:
193.5±15.0 °C

[ Exact Mass ]:
160.052429

[ PSA ]:
40.46000

[ LogP ]:
1.98

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.726

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ4743333

CHEMICAL NAME :: 1,6-Naphthalenediol

CAS REGISTRY NUMBER :: 575-44-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 umol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 371,293,1996

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
QJ4743333

[ HS Code ]:
2907299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2907299090

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Articles

Genome-based discovery of a novel membrane-bound 1,6-dihydroxyphenazine prenyltransferase from a marine actinomycete.

PLoS ONE 9(6) , e99122, (2014)

Recently, novel prenylated derivatives of 1,6-dihydroxyphenazine have been isolated from the marine sponge-associated Streptomyces sp. SpC080624SC-11. Genome sequencing of this strain now revealed a g...

Selective antiproliferative activity of hydroxynaphthyl-beta-D-xylosides.

J. Med. Chem. 49 , 1932-8, (2006)

The antiproliferative activity of the 14 isomeric monoxylosylated dihydroxynaphthalenes has been tested in vitro toward normal HFL-1 and 3T3 A31 cells as well as transformed T24 and 3T3 SV40 cells. Th...

Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities.

Bioorg. Med. Chem. 16 , 8117-26, (2008)

NphB is a soluble prenyltransferase from Streptomyces sp. strain CL190 that attaches a geranyl group to a 1,3,6,8-tetrahydroxynaphthalene-derived polyketide during the biosynthesis of anti-oxidant nap...