MCL0129 tetrahydrochloride

Names

[ Name ]:
MCL0129 tetrahydrochloride

[Synonym ]:
Piperazine, 1-[(1S)-1-(4-fluorophenyl)-2-[4-[4-(2-methoxy-1-naphthalenyl)butyl]-1-piperazinyl]ethyl]-4-(1-methylethyl)-, hydrochloride (1:4)
1-[(2S)-2-(4-Fluorophenyl)-2-(4-isopropyl-1-piperazinyl)ethyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine tetrahydrochloride

Biological Activity

[Description]:

MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3; attenuates the alpha-MSH-increased cAMP formation in COS-1 cells expressing the MC4, does not affect basal cAMP levels; exhibits anxiolytic- and antidepressant-like activities in various rodent models. Depression Discontinued

[References]

References 1. Chaki S, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):818-26. 2. Shimazaki T, et al. Pharmacol Biochem Behav. 2005 Mar;80(3):395-400. View Related Products by Target Melanocortin Receptor Depression

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₄H₅₁Cl₄FN₄O

Related Compounds

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