MK-2295

Names

[ CAS No. ]:
573678-04-3

[ Name ]:
MK-2295

Biological Activity

[Description]:

MK-2295 (NGD-8243) is a TRPV1 antagonist. MK-2295 is an analgesic agent, and can be used for research of pain[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Inflammation/Immunology

[Target]

TRPV1

[References]

[1]. Gunthorpe MJ, et al. Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway. Drug Discov Today. 2009 Jan;14(1-2):56-67.

[2]. Arthur Gomtsyan, et al. Chapter 8 - Clinical and Preclinical Experience with TRPV1 Antagonists as Potential Analgesic Agents. TRP Channels as Therapeutic Targets. From Basic Science to Clinical Use. 2015, Pages 129-144.

Chemical & Physical Properties

[ Density]:
1.440±0.06 g/cm3(Predicted)

[ Boiling Point ]:
500.9±50.0 °C(Predicted)

[ Molecular Formula ]:
C₂₁H₁₂F₆N₄

[ Molecular Weight ]:
434.34

Related Compounds

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