Ayanin

Names

[ CAS No. ]:
572-32-7

[ Name ]:
Ayanin

[Synonym ]:
3',5-Dihydroxy-3,4',7-trimethoxyflavone
3,4',7-O-trimethylquercetin
4H-1-Benzopyran-4-one, 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxy-
5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one
quercetin-3,4',7-trimethyl ether
3,7,4'-trimethylquercetin
3,7,4'-trimethoxy-5,3'-dihydroxyflavone
5,3'-Dihydroxy-3,7,4'-trimethoxyflavone
Ayanin
3,7,4'-Tri-O-methylquercetin
3',5-dihydroxy-3,4',7-trimethoxy-flavone

Biological Activity

[Description]:

Ayanin is a bioflavonoid isolated from Croton schiedeanus Schlecht. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for the study of respiratory disease,such as allergic asthma et al[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Inflammation/Immunology

[Target]

PDE2A

PDE4

[In Vitro]

Ayanin inhibits interleukin (IL)-4 production from purified basophils with an IC50 value of 2.2 μM[1].

[References]

[1]. Fei-Peng Lee, et al. Ayanin, a Non-Selective Phosphodiesterase 1-4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness Without Affecting xylazine/ketamine-induced Anesthesia. Eur J Pharmacol. 2010 Jun 10;635(1-3):198-203.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
600.8±55.0 °C at 760 mmHg

[ Melting Point ]:
173℃

[ Molecular Formula ]:
C₁₈H₁₆O₇

[ Molecular Weight ]:
344.315

[ Flash Point ]:
221.5±25.0 °C

[ Exact Mass ]:
344.089600

[ PSA ]:
98.36000

[ LogP ]:
2.43

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.654

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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