Norstictic Acid

Names

[ CAS No. ]:
571-67-5

[ Name ]:
Norstictic Acid

[Synonym ]:
Bryopogonic acid

Biological Activity

[Description]:

Norstictic acid is a potent and selective allossteric transcriptional regulator. Norstictic acid shows anticancer activity. Norstictic acid shows antioxidant activity and antimicrobial activity[1][2][3][4].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Norstictic acid significantly suppresses the TNBC MDA-MB-231 cell proliferation, migration, invasion with low toxicity[2].

[References]

[1]. Garlick JM, et al. Norstictic Acid Is a Selective Allosteric Transcriptional Regulator. J Am Chem Soc. 2021 Jun 30;143(25):9297-9302.

[2]. Ebrahim HY, et al. Norstictic Acid Inhibits Breast Cancer Cell Proliferation, Migration, Invasion, and In Vivo Invasive Growth Through Targeting C-Met. Phytother Res. 2016 Apr;30(4):557-66.

[3]. Ranković B, et al. Biological activities of Toninia candida and Usnea barbata together with their norstictic acid and usnic acid constituents. Int J Mol Sci. 2012 Nov 12;13(11):14707-22.

[4]. Tay T, et al. Evaluation of the antimicrobial activity of the acetone extract of the lichen Ramalina farinacea and its (+)-usnic acid, norstictic acid, and protocetraric acid constituents. Z Naturforsch C J Biosci. 2004 May-Jun;59(5-6):384-8.

Chemical & Physical Properties

[ Density]:
1.714g/cm3

[ Boiling Point ]:
764.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₁₂O₉

[ Molecular Weight ]:
372.28200

[ Flash Point ]:
283.7ºC

[ Exact Mass ]:
372.04800

[ PSA ]:
139.59000

[ LogP ]:
2.01330

[ Index of Refraction ]:
1.747

Related Compounds

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