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penduletin

Names

[ CAS No. ]:
569-80-2

[ Name ]:
penduletin

[Synonym ]:
5,4'-Dihydroxy-3,6,7-trimethoxyflavone
4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-3,6,7-trimethoxy-
6-OH-kaempferol-3,6,7-trimethylether
5-Hydroxy-2-(4-hydroxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one
Penduletin
5-Hydroxy-2-(4-hydroxyphenyl)-3,6,7-trimethoxy-4H-chromen-4-one
4',5-dihydroxy-3,6,7-trimethoxy-flavone

Biological Activity

[Description]:

Penduletin is a flavone, that can be isolated from Brickelia pendula and Vitex negundo. Penduletin shows anticancer activity. Penduletin induces apoptosis in the cancer cells through ROS generation[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[References]

[1]. Flores S E, et al.The structure of pendulin and penduletin: a new flavonol glucoside isolated from brickelia pendula[J].Tetrahedron, 1958, 2(3-4):308-315.

[2]. Vo GV, et al. In silico and in vitro studies on the anti-cancer activity of artemetin, vitexicarpin and penduletin compounds from Vitex negundo. Saudi Pharm J. 2022 Sep;30(9):1301-1314.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
595.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H16O7

[ Molecular Weight ]:
344.32

[ Flash Point ]:
219.3±23.6 °C

[ Exact Mass ]:
344.089600

[ PSA ]:
98.36000

[ LogP ]:
2.49

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.654

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds