TLR1

Names

[ Name ]:
TLR1

Biological Activity

[Description]:

TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> MyD88

[In Vitro]

TLR1 inhibits IL-1β-induced phosphorylation of the mitogen-activated protein kinase p38 in EL4 thymoma cells and in freshly isolated murine lymphocytes in a concentration-dependent manner[1].

[In Vivo]

TLR1 interferes with the interactions between mouse MyD88 and IL-1RI at the TIR domains. TLR1 produces a significant attenuation of the IL-1β-induced fever response (200 mg/kg, i.p.)[1].

[References]

[1]. Bartfai T, et al. A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7971-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₆N₂O₂

[ Molecular Weight ]:
302.41100

[ Exact Mass ]:
302.19900

[ PSA ]:
49.41000

[ LogP ]:
2.71120

Related Compounds

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