STE-MEK1(13)

Names

[ CAS No. ]:
566872-15-9

[ Name ]:
STE-MEK1(13)

Biological Activity

[Description]:

STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH?) is a cell permeable ERK1/2 inhibitor (IC50: 13-30?μM). STE-MEK1(13) inhibits ERK1/2 phosphorylation[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> ERK
Signaling Pathways >> Stem Cell/Wnt >> ERK

[Target]

13-30?μM (ERK1/2)[1]


[References]

[1]. Li G, et al. A novel cellular survival factor--the B2 subunit of vacuolar H+-ATPase inhibits apoptosis. Cell Death Differ. 2006 Dec;13(12):2109-17.  

[2]. Whiteman M, et al. Peroxynitrite-modified collagen-II induces p38/ERK and NF-kappaB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells. Osteoarthritis Cartilage. 2006 May;14(5):460-70.  

Chemical & Physical Properties

[ Molecular Formula ]:
C86H153N19O17S

[ Molecular Weight ]:
1757.32

Related Compounds

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