irisquinone

Irisquinone, a natural product, is an anticancer agent. Irisquinone is also a radiation sensitizer for cancer. Irisquinone reduces GSH level and inhibits the repair of DNA singular strand breaks[1][2][3].

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Irisquinone (0-128 nM, 12-48 h) 诱导大鼠 C6 胶质瘤细胞死亡[2]。 Irisquinone (4.2 nM, 48 h) 增加大鼠 C6 神经胶质瘤细胞的放射敏感性[2]。 Cell Viability Assay[2] Cell Line: C6 rat glioma cells Concentration: 0, 4, 8, 16, 32, 64, 128 nM Incubation Time: 12, 24, 48 h Result: Time-dependently and dose-dependently inhibited cell viability.

Irisquinone (12.5 mg/kg，每日灌注) 使兔 VX2肺移植肿瘤模型中 Irisquinone + 放疗组瘤壁变薄，坏死面积变大[1]。 Animal Model: Rabbit bearing VX2 lung transplant tumor[1] Dosage: 12.5 mg/kg Administration: Perfused daily, starting from 3 days before irradiation to the end of irradiation. Result: Displayed no significant difference of tumor growth between the radio therapy and Irisquinone + radiotherapy groups. Showed thinner tumor wall and the larger necrotic area in the Irisquinone + radiotherapy group.

[1]. Xu H, et al. Dynamic observation of the radiosensitive effect of irisquinone on rabbit VX2 lung transplant tumors by using fluorine-18-deoxyglucose positron emission tomography/computed tomography. Nucl Med Commun. 2013 Mar;34(3):220-8.  

[2]. Wang H, et al. Radiosensitizing effect of irisquinone on glioma through the downregulation of HIF-1α evaluated by 18F-FDG and 18F-FMISO PET/CT. Nucl Med Commun. 2016 Jul;37(7):705-14.  

[3]. Liang, l., et al. The effect of Irisquinone on the glutathione system and MRP expression of cisplatin-resistant human lung adenocarcinoma cell line (A DDP549). Chin J Cancer Res 13, 171–175 (2001).

MOLECULAR FORMULA :

C24-H38-O3

MOLECULAR WEIGHT :

374.62

WISWESSER LINE NOTATION :

L6V DVJ BO1 F10U7

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 2,131,1981

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

25400 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 2,131,1981