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Ambuphylline

Names

[ CAS No. ]:
5634-34-4

[ Name ]:
Ambuphylline

[Synonym ]:
Butaphyllamine
AMBUPHYLLINE
Bufylline
EINECS 227-077-5
Theophylline aminoisobutanol
Buthoid

Biological Activity

[Description]:

Ambuphylline (Bufylline) is a bronchodilator. Ambuphylline is a theophylline derivative possibly acting through phosphodiesterase inhibition. Ambuphylline can be used for the research of asthma and other lung diseases[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Chemical & Physical Properties

[ Boiling Point ]:
454.1ºC at 760 mmHg

[ Molecular Formula ]:
C11H19N5O3

[ Molecular Weight ]:
269.30000

[ Flash Point ]:
228.4ºC

[ Exact Mass ]:
269.14900

[ PSA ]:
118.93000

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH4375000
CAS REGISTRY NUMBER :
5634-34-4
LAST UPDATED :
199107
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H8-N4-O2.C4-H11-N-O
MOLECULAR WEIGHT :
269.35
WISWESSER LINE NOTATION :
ZX1Q &622 &T56 BM DN FNVMVJ F H &621

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 31,1337,1946
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
163 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 31,1337,1946

Related Compounds

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