7-chloro-N-methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxamide

Names

[ Name ]:
7-chloro-N-methyl-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepine-3-carboxamide

[Synonym ]:
7-Chloro-2,3-dihydro-N-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxamide
D-58M
1H-1,4-Benzodiazepine-3-carboxamide,2,3-dihydro-7-chloro-N-methyl-2-oxo-5-phenyl
1-Methylcarbamoyldiazepam

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₄ClN₃O₂

[ Molecular Weight ]:
327.76500

[ Exact Mass ]:
327.07700

[ PSA ]:
77.54000

[ LogP ]:
2.60510

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE8747930

CHEMICAL NAME :: 1H-1,4-Benzodiazepine-3-carboxamide, 2,3-dihydro-7-chloro-N-methyl-2-oxo-5-phenyl-

CAS REGISTRY NUMBER :: 5606-59-7

BEILSTEIN REFERENCE NO. :: 0690746

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H14-Cl-N3-O2

MOLECULAR WEIGHT :: 327.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 840 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,134,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 29,134,1970

Related Compounds

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