4-Chloro-6-methyl-2-pyrimidinamine
Names
[ CAS No. ]:
5600-21-5
[ Name ]:
4-Chloro-6-methyl-2-pyrimidinamine
[Synonym ]:
4-Chloro-6-methyl-2-pyrimidinamine
2-Pyrimidinamine, 4-chloro-6-methyl-
4-chloro-6-methylpyrimidin-2-amine
2-Amino-4-chloro-6-methylpyrimidine
ACMP
MFCD00006091
EINECS 227-018-3
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
326.0±34.0 °C at 760 mmHg
[ Melting Point ]:
183-186 °C(lit.)
[ Molecular Formula ]:
C5H6ClN3
[ Molecular Weight ]:
143.574
[ Flash Point ]:
151.0±25.7 °C
[ Exact Mass ]:
143.025024
[ PSA ]:
51.80000
[ LogP ]:
1.04
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.600
[ Storage condition ]:
-20°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UV6329600
- CHEMICAL NAME :
- Pyrimidine, 2-amino-4-chloro-6-methyl-
- CAS REGISTRY NUMBER :
- 5600-21-5
- BEILSTEIN REFERENCE NO. :
- 0114297
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C5-H6-Cl-N3
- MOLECULAR WEIGHT :
- 143.59
- WISWESSER LINE NOTATION :
- T6N CNJ BZ DG F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Microorganism - not otherwise specified
- DOSE/DURATION :
- 50 mg/L
- REFERENCE :
- SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 6,1623,1970
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S22-S24/25-S37/39-S26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
UV6329600
[ HS Code ]:
29335995
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933599090
[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Pharmaceutics 3 , 601-14, (2013)
In the pharmaceutical industry, co-crystals are becoming increasingly valuable as crystalline solids that can offer altered/improved physical properties of an active pharmaceutical ingredient (API) wi...
Vibrational spectra, UV and NMR, first order hyperpolarizability and HOMO-LUMO analysis of 2-amino-4-chloro-6-methylpyrimidine.Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 97 , 811-24, (2012)
The solid phase FTIR and FT-Raman spectra of 2-amino-4-chloro-6-methylpyrimidine (2A4Cl6MP) have been recorded in the regions 400-4000 and 50-4,000 cm(-1), respectively. The spectra have been interpre...
Inhibition of thiaminase I from Bacillus thiaminolyticus. Evidence supporting a covalent 1,6-dihydropyrimidinyl-enzyme intermediate.Biochemistry 26(7) , 1969-73, (1987)
Thiaminase I from Bacillus thiaminolyticus strain Matsukawa et Misawa is completely and irreversibly inhibited by treatment with 4-amino-6-chloro-2-methylpyrimidine. Inhibition is a time-dependent fir...