4-Chloro-6-methyl-2-pyrimidinamine

Names

[ Name ]:
4-Chloro-6-methyl-2-pyrimidinamine

[Synonym ]:
4-Chloro-6-methyl-2-pyrimidinamine
2-Pyrimidinamine, 4-chloro-6-methyl-
4-chloro-6-methylpyrimidin-2-amine
2-Amino-4-chloro-6-methylpyrimidine
ACMP
MFCD00006091
EINECS 227-018-3

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
326.0±34.0 °C at 760 mmHg

[ Melting Point ]:
183-186 °C(lit.)

[ Molecular Formula ]:
C₅H₆ClN₃

[ Molecular Weight ]:
143.574

[ Flash Point ]:
151.0±25.7 °C

[ Exact Mass ]:
143.025024

[ PSA ]:
51.80000

[ LogP ]:
1.04

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.600

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV6329600

CHEMICAL NAME :: Pyrimidine, 2-amino-4-chloro-6-methyl-

CAS REGISTRY NUMBER :: 5600-21-5

BEILSTEIN REFERENCE NO. :: 0114297

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C5-H6-Cl-N3

MOLECULAR WEIGHT :: 143.59

WISWESSER LINE NOTATION :: T6N CNJ BZ DG F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 50 mg/L

REFERENCE :: SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 6,1623,1970

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25-S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UV6329600

[ HS Code ]:
29335995

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Co-crystal screening of diclofenac.

Pharmaceutics 3 , 601-14, (2013)

In the pharmaceutical industry, co-crystals are becoming increasingly valuable as crystalline solids that can offer altered/improved physical properties of an active pharmaceutical ingredient (API) wi...

Vibrational spectra, UV and NMR, first order hyperpolarizability and HOMO-LUMO analysis of 2-amino-4-chloro-6-methylpyrimidine.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 97 , 811-24, (2012)

The solid phase FTIR and FT-Raman spectra of 2-amino-4-chloro-6-methylpyrimidine (2A4Cl6MP) have been recorded in the regions 400-4000 and 50-4,000 cm(-1), respectively. The spectra have been interpre...

Inhibition of thiaminase I from Bacillus thiaminolyticus. Evidence supporting a covalent 1,6-dihydropyrimidinyl-enzyme intermediate.

Biochemistry 26(7) , 1969-73, (1987)

Thiaminase I from Bacillus thiaminolyticus strain Matsukawa et Misawa is completely and irreversibly inhibited by treatment with 4-amino-6-chloro-2-methylpyrimidine. Inhibition is a time-dependent fir...