2-(3,4-dichlorophenyl)-3-methyl-1,1-dioxo-1,3-thiazinan-4-one
Names
[ CAS No. ]:
5571-97-1
[ Name ]:
2-(3,4-dichlorophenyl)-3-methyl-1,1-dioxo-1,3-thiazinan-4-one
[Synonym ]:
Dichlormethazanone
2-(3,4-Dichlorophenyl)-3-methyl-4-metathiazanone 1,1-dioxide
(-)-2-(3,4-Dichlorphenyl)-tetrahydro-3-methyl-4H-1,3-thiazin-4-on-1,1-dioxid
Dichlormezanonum [INN-Latin]
Diclormezanona [INN-Spanish]
2-(3,4-dichlorophenyl)-3-methyl-1,3-thiazinan-4-one 1,1-dioxide
Dichlormezanone
Chemical & Physical Properties
[ Density]:
1.476g/cm3
[ Boiling Point ]:
555.4ºC at 760 mmHg
[ Molecular Formula ]:
C11H11Cl2NO3S
[ Molecular Weight ]:
308.18100
[ Flash Point ]:
289.7ºC
[ Exact Mass ]:
306.98400
[ PSA ]:
62.83000
[ LogP ]:
3.28760
[ Index of Refraction ]:
1.588
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XJ1225000
- CHEMICAL NAME :
- 4H-1,3-Thiazin-4-one, 2-(3,4-dichlorophenyl)tetrahydro-3-methyl-, 1,1-dioxide
- CAS REGISTRY NUMBER :
- 5571-97-1
- LAST UPDATED :
- 199206
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C11-H11-Cl2-N-O3-S
- MOLECULAR WEIGHT :
- 308.19
- WISWESSER LINE NOTATION :
- T6VN DSWTJ B1 CR CG DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1050 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,168,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 840 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 122,517,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 570 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,168,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,168,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,168,1959 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3975 mg/kg/5D-C
- TOXIC EFFECTS :
- Related to Chronic Data - death
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,168,1959
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 14445 mg/kg/54W-I
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,168,1959