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mollugin

Names

[ CAS No. ]:
55481-88-4

[ Name ]:
mollugin

[Synonym ]:
Methyl 6-hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate
5-Carbomethoxy-6-hydroxy-2,2-dimethyl-2H-naphtho<1,2-b>-pyran
2H-Naphtho[1,2-b]pyran-5-carboxylic acid, 6-hydroxy-2,2-dimethyl-, methyl ester
Rubimaillin
Mollugin/rubiMaillin
6-hydroxy-2,2-dimethyl-,methylester
mollugin

Biological Activity

[Description]:

Mollugin is a major bioactive component isolated from Rubia cordifolia L.. Mollugin has an anti-cancer therapeutic effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 via the p38-Smad signaling pathway [1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Wang Z, et al. Mollugin Has an Anti-Cancer Therapeutic Effect by Inhibiting TNF-α-Induced NF-κB Activation. Int J Mol Sci. 2017 Jul 26;18(8).

[2]. Moon SH, et al. Mollugin enhances the osteogenic action of BMP-2 via the p38-Smad signaling pathway. Arch Pharm Res. 2017 Nov;40(11):1328-1335.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
453.2±45.0 °C at 760 mmHg

[ Melting Point ]:
132-134ºC

[ Molecular Formula ]:
C17H16O4

[ Molecular Weight ]:
284.306

[ Flash Point ]:
167.5±22.2 °C

[ Exact Mass ]:
284.104858

[ PSA ]:
55.76000

[ LogP ]:
5.16

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.619

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
29329990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds