ANTHRAMYCIN METHYL ETHER
Names
[ CAS No. ]:
5544-25-2
[ Name ]:
ANTHRAMYCIN METHYL ETHER
[Synonym ]:
Roche 5-9000
Anthramycin-methylether
Antibiotic A
Anthramycin 11-methyl ether
11-O-Methyl-anthramycin
Chemical & Physical Properties
[ Density]:
1.4g/cm3
[ Boiling Point ]:
631.8ºC at 760 mmHg
[ Molecular Formula ]:
C17H19N3O4
[ Molecular Weight ]:
329.35000
[ Flash Point ]:
335.9ºC
[ Exact Mass ]:
329.13800
[ PSA ]:
104.89000
[ LogP ]:
2.01470
[ Index of Refraction ]:
1.672
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UY8429500
- CHEMICAL NAME :
- 1H-Pyrrolo(2,1-c)(1,4)benzodiazepine-2-acrylamide, 5,10,11,11a-tetrahydro-9-hydroxy- 11-methoxy-8-methyl-5-oxo-, (E)-, monohydrate
- CAS REGISTRY NUMBER :
- 5544-25-2
- LAST UPDATED :
- 199306
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C17-H19-N3-O4.H2-O
- MOLECULAR WEIGHT :
- 347.41
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 730 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- DNA inhibition
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - mouse Ascites tumor
- DOSE/DURATION :
- 5 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 29,2195,1969