3-hydroxypyrazine-2-carboxamide

Names

[ Name ]:
3-hydroxypyrazine-2-carboxamide

[Synonym ]:
Pyrazine-2-carboxamide, 3-hydroxy-
2-pyrazinecarboxamide, 3-hydroxy-
3-Oxo-3,4-dihydropyrazine-2-carboxamide
T6N DNJ BVZ CQ
T6MV DNJ CVZ
2-oxo-1H-pyrazine-3-carboxamide
3-hydroxypyrazine-2-carboxamide
Pyrazinecarboxamide, 3,4-dihydro-3-oxo-

Biological Activity

[Description]:

T-1105, a novel broad-spectrum viral polymerase inhibitor, structural analogue of T-705, inhibits the polymerases of RNA viruses after being converted to ribonucleoside triphosphate (RTP) metabolite[1]. T-1105 has antiviral activity against various RNA viruses, including Zika virus (ZIKV), influenza virus, arenaviruses, bunyaviruses, West Nile virus (WNV), yellow fever virus (YFV), and foot-and-mouth disease virus (FMDV). T-1105 can be formed by nicotinamide mononucleotide adenylyltransferase[2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

[Target]

Viral polymerase[1]

[References]

[1]. Huchting J, et al. Cell line-dependent activation and antiviral activity of T-1105, the non-fluorinated analogue of T-705 (favipiravir). Antiviral Res. 2019 Jul;167:1-5.

[2]. Furuta Y, et al. T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections. Antiviral Res. 2009 Jun;82(3):95-102.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
640.8±55.0 °C at 760 mmHg

[ Melting Point ]:
ca 270℃

[ Molecular Formula ]:
C₅H₅N₃O₂

[ Molecular Weight ]:
139.112

[ Flash Point ]:
341.3±31.5 °C

[ Exact Mass ]:
139.038177

[ PSA ]:
89.10000

[ LogP ]:
0.32

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.634

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-37

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.