3,4-Dihydroquinolin-2(1H)-one

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
328.1±31.0 °C at 760 mmHg

[ Melting Point ]:
165-167ºC

[ Molecular Formula ]:
C₉H₉NO

[ Molecular Weight ]:
147.174

[ Flash Point ]:
189.4±9.8 °C

[ Exact Mass ]:
147.068420

[ PSA ]:
29.10000

[ LogP ]:
1.34

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.564

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H317-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38;R43

[ Safety Phrases ]:
S26-S36/37

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
2

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Click to get detail synthetic route

Precursor

DownStream

Synthesis and biological evaluation of a novel sigma-1 receptor antagonist based on 3,4-dihydro-2(1H)-quinolinone scaffold as a potential analgesic.

Eur. J. Med. Chem. 79 , 216-30, (2014)

The synthesis and sigma-1 receptor (1R) antagonist activity of a new series of 3,4-dihydro-2(1H)-quinolinone derivatives are reported. The new compounds were evaluated in vitro in sigma-1 and sigma-2 ...

Novel approach to 3,4-dihydro-2(1H)-quinolinone derivatives via cyclopropane ring expansion.

Org. Lett. 11(5) , 1043-5, (2009)

N-(1'-Alkoxy)cyclopropyl-2-haloanilines are transformed to 3,4-dihydro-2((1)H)-quinolinones via palladium-catalyzed cyclopropane ring expansion. The reaction tolerates a variety of functional groups s...

Synthesis of 4-amino-3, 4-dihydro-2 (1H)-quinolinones via β-lactam intermediates on the solid-phase. Pei Y, et al.

Tetrahedron Lett. 38(19) , 3349-52, (1997)

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