sodium,(Z,2S)-2-[[(Z,2S)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-6-diazonio-5-oxidohex-5-enoyl]amino]-6-diazonio-5-oxidohex-5-enoate
Names
[ CAS No. ]:
55156-24-6
[ Name ]:
sodium,(Z,2S)-2-[[(Z,2S)-2-[[(4S)-4-amino-4-carboxybutanoyl]amino]-6-diazonio-5-oxidohex-5-enoyl]amino]-6-diazonio-5-oxidohex-5-enoate
[Synonym ]:
Antibiotic 1719 sodium salt
Azotomycin sodium salt
Azotomycin sodium
1719 Sodium
Chemical & Physical Properties
[ Molecular Formula ]:
C17H22N7NaO8
[ Molecular Weight ]:
475.38800
[ Exact Mass ]:
475.14300
[ PSA ]:
271.05000
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RC6311000
- CHEMICAL NAME :
- L-Norleucine, 6-diazo-N-(6-diazo-N-L-gamma-glutamyl-5-oxo-L-norleuc yl)-5-oxo-, sodium salt
- CAS REGISTRY NUMBER :
- 55156-24-6
- LAST UPDATED :
- 199509
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C17-H23-N7-O8.xNa
- MOLECULAR WEIGHT :
- 614.40
- WISWESSER LINE NOTATION :
- QVYZ2VMY2V1UNN&VMYVQ2V1UNN &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 388 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 262 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Liver - other changes
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 23,3467,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 271 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4300 ug/kg/5D-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of endocrine pancreas Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) Related to Chronic Data - death
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 23,3467,1974