1-phenylbiguanide hydrochloride
Names
[ CAS No. ]:
55-57-2
[ Name ]:
1-phenylbiguanide hydrochloride
[Synonym ]:
Phenylbiguanide monohydrochloride
Phenylbiguanide hydrochloride
1-phenylbiguanide hydrochloride
MFCD00035040
N-phenylbiguanide hydrochloride
Phenyldiguanide hydrochloride
EINECS 200-239-2
N'-Phenylbiguanide monohydrochloride
N-phenylimidodicarbonimidic diamide hydrochloride
1-Phenylbiquanide hydrochloride
1-Phenylbiguanide monohydrochloride
1-phenyl-biguanidium chloride
1-phenyl-biguanide hydrogenchloride
Chemical & Physical Properties
[ Density]:
1.33g/cm3
[ Boiling Point ]:
388.4ºC at 760mmHg
[ Melting Point ]:
244-247ºC(lit.)
[ Molecular Formula ]:
C8H12ClN5
[ Molecular Weight ]:
213.66700
[ Flash Point ]:
188.7ºC
[ Exact Mass ]:
213.07800
[ PSA ]:
97.78000
[ LogP ]:
2.68200
[ Storage condition ]:
Store at RT
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DU2550000
- CHEMICAL NAME :
- Biguanide, 1-phenyl-, monohydrochloride
- CAS REGISTRY NUMBER :
- 55-57-2
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C8-H11-N5.Cl-H
- MOLECULAR WEIGHT :
- 213.70
- WISWESSER LINE NOTATION :
- MUYZMYUM&MR &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 1,434,1952
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 243 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 6,117,1974
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xn
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
DU2550000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Toxicon 57(2) , 193-8, (2011)
Pulmonary edema is a consistent feature of Mesobuthus tamulus (MBT) envenomation. Kinins, prostaglandins and other inflammatory mediators are implicated in it. Since, histamine also increases capillar...
Effect of 3,5-dicarbomethoxyphenylbiguanide on free radical homeostasis in rats with experimental myocarditis.Bull. Exp. Biol. Med. 154(2) , 192-5, (2012)
Administration of 3,5-dicarbomethoxyphenylbiguanide to rats with experimental epinephrine-induced myocarditis was followed by a decrease in activity of marker enzymes for cardiomyocyte cytolysis in th...
B(2) kinin receptors mediate the Indian red scorpion venom-induced augmentation of visceral reflexes via the nitric oxide cyclic guanosine monophosphate pathway.Acta Physiol. (Oxf.) 196(4) , 365-73, (2009)
This study was performed to delineate the kinin (receptor)-dependent pathways in the Indian red scorpion (Mesobuthus tamulus; MBT) venom-induced pulmonary oedema as well as the augmentation of cardio-...