(−)-Scopolamine hydrochloride
Names
[ CAS No. ]:
55-16-3
[ Name ]:
(−)-Scopolamine hydrochloride
[Synonym ]:
scopolamine HCl
UNII-Q2P66EIP1F
Scopolamine hydrochloride
hyoscine hydrochloride
SCOPINE TROPATE
chlorhydratedescopolamine
(1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.0]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate hydrochloride (1:1)
Benzeneacetic acid, α-(hydroxymethyl)-, (1R,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0]non-7-yl ester, (αS)-, hydrochloride (1:1)
EINECS 200-225-6
(-)-Scopolamine hydrochloride
er),hcl
SCOPINE TROPATE HYDROCHLORIDE
ScopolamineSeries
MFCD00058096
Chemical & Physical Properties
[ Boiling Point ]:
460.3ºC at 760mmHg
[ Molecular Formula ]:
C17H22ClNO4
[ Molecular Weight ]:
339.814
[ Flash Point ]:
232.2ºC
[ Exact Mass ]:
339.123749
[ PSA ]:
62.30000
[ LogP ]:
1.65800
[ Storage condition ]:
?20°C
[ Water Solubility ]:
H2O: 50 mg/mL
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CY1634501
- CHEMICAL NAME :
- Benzeneacetic acid, alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(sup 2,4)) non-7-yl ester, hydrochloride, (7(S)-(1-alpha,2-beta,4-beta,5-alpha,7-beta))-
- CAS REGISTRY NUMBER :
- 55-16-3
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C17-H21-N-O4.Cl-H
- MOLECULAR WEIGHT :
- 339.85
- WISWESSER LINE NOTATION :
- T C356 A AN DOTJ A1 HOVYR&1Q &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1275 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 88,713,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 104 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - parasympatholytic
- REFERENCE :
- ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 29,39,1972
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H300 + H310 + H330
[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P302 + P350
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T+: Very toxic;
[ Risk Phrases ]:
R26/27/28
[ Safety Phrases ]:
S25-S45
[ RIDADR ]:
UN 1544
[ WGK Germany ]:
3
[ RTECS ]:
CY1634501
Articles
J. Neurosci. 35(14) , 5680-92, (2015)
Cholinergic [acetylcholine (ACh)] axons from the basal forebrain innervate olfactory bulb glomeruli, the initial site of synaptic integration in the olfactory system. Both nicotinic acetylcholine rece...
Synthesis and preliminary ex vivo evaluation of the spasmolytic activity of 1,3-thiazolium- and 1,3,4-thiadiazolium-5-methylthio- and 5-thioacetate derivatives.Acta. Pharm. 64(2) , 233-45, (2014)
Seven new compounds have been synthetized in satisfactory yields (51-78 %) through the treatment of mesoionic 1,3-thiazolium-5-thiolate (4a-d) and 1,3,4-thiadiazolium- 5-thiolate (10a,b) with chloroac...
Preventive effect of baicalein on methamphetamine-induced amnesia in the passive avoidance test in mice.Pharmacology 93(5-6) , 278-85, (2014)
Methamphetamine abuse may produce cognitive impairment. Baicalein, a bioactive flavonoid, has antioxidative, anti-inflammatory and neuroprotective effects. This study examined the effects of baicalein...