Chiniofon

Names

[ CAS No. ]:
547-91-1

[ Name ]:
Chiniofon

[Synonym ]:
7-iodo-8-hydroxyquinoline-5-sulphonic acid
7-iodo-8-hydroxyquinoline-5-sulfonic acid
Chinoiodine
quiniophen
Chinoiodin
UNII-6E8Y02XFEI
meditrene
EINECS 208-938-4
8-hydroxy-7-iodoquinoline-5-sulfonic acid
ferron
CHINIOFON ACID
5-Quinolinesulfonic acid, 8-hydroxy-7-iodo-
LORETIN
m-Iodo-o-hydroxyquinolineanasulfonic Acid
MFCD00006793
7-Iodo-8-hydroxyquinolinium 5-sulfonate
8-hydroxy-7-iodoquinolinium-5-sulphonate
8-Hydroxy-7-iodo-5-quinolinesulfonic acid
Chiniofon
yellon
8-hydroxy-7-iodoquinoline-5-sulphonic acid
Quiniofon
7-Iodo-8-Hydroxychinolin 5-Sulphonic Acid

Biological Activity

[Description]:

Ferron (8-Hydroxy-7-iodo-5-quinolinesulfonic acid) has antiseptic and antifungal activity. Ferron can prevent skin and mucosa bacterial irritations and inflammations[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Pippi B, et al. New insights into the mechanism of antifungal action of 8-hydroxyquinolines. Saudi Pharm J. 2019 Jan;27(1):41-48.

Chemical & Physical Properties

[ Density]:
2.2±0.1 g/cm3

[ Melting Point ]:
269-270 °C (dec.)(lit.)

[ Molecular Formula ]:
C₉H₆INO₄S

[ Molecular Weight ]:
351.12

[ Exact Mass ]:
350.906219

[ PSA ]:
95.87000

[ LogP ]:
0.38

[ Index of Refraction ]:
1.776

[ Stability ]:
Stable.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC2800000

CHEMICAL NAME :: 5-Quinolinesulfonic acid, 8-hydroxy-7-iodo-

CAS REGISTRY NUMBER :: 547-91-1

BEILSTEIN REFERENCE NO. :: 0223832

LAST UPDATED :: 199706

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H6-I-N-O4-S

MOLECULAR WEIGHT :: 351.12

WISWESSER LINE NOTATION :: T66 BNJ GSWQ II JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 3,44,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 63,122,1938

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 63,122,1938

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 43,495,1954

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2585 8/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
VC2800000

[ Packaging Group ]:
III

[ Hazard Class ]:
8.0

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Hydroxyl radicals cause fluctuation in intracellular ferrous ion levels upon light exposure during photoreceptor cell death.

Exp. Eye Res. 129 , 24-30, (2014)

Iron accumulation is a potential pathogenic event often seen in age-related macular degeneration (AMD) patients. In this study, we focused on the relationship between AMD pathology and concentrations ...

Proton-transfer compounds of 8-hydroxy-7-iodoquinoline-5-sulfonic acid (ferron) with 4-chloroaniline and 4-bromoaniline.

Acta Crystallogr. C 63(Pt 7) , o405-7, (2007)

The crystal structures of the proton-transfer compounds of ferron (8-hydroxy-7-iodoquinoline-5-sulfonic acid) with 4-chloroaniline and 4-bromoaniline, namely 4-chloroanilinium 8-hydroxy-7-iodoquinolin...

Polyaluminum chloride with high Al30 content as removal agent for arsenic-contaminated well water.

Water Res. 46(1) , 53-62, (2012)

Polyaluminum chloride (PACl) is a well-established coagulant in water treatment with high removal efficiency for arsenic. A high content of Al(30) nanoclusters in PACl improves the removal efficiency ...

Related Compounds

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