Conessine
Names
[ CAS No. ]:
546-06-5
[ Name ]:
Conessine
[Synonym ]:
3β-(Dimethylamino)con-5-enine
3-β-(Dimethylamino)con-5-enine
CONESSIN
Conessine
Con-5-enin-3-amine, N,N-dimethyl-, (3β)-
(3S,3aS,5aS,5bR,9S,11aR,11bS,13aR)-N,N,2,3,11a-Pentamethyl-2,3,3a,4,5,5a,5b,6,8,9,10,11,11a,11b,12,13-hexadecahydro-1H-naphtho[2',1':4,5]indeno[1,7a-c]pyrrol-9-amine
Konessin
ROGUESSINE
Conessine,N,N-Dimethyl-con-5-enin-3-amine
(3β)-N,N-Dimethylcon-5-enin-3-amine
ROQUESSINE
Wrightine
NERVINE
3β-(Dimethylamino)con-5-ene
(3b)-N,N-Dimethylcon-5-enin-3-amine
3b-(Dimethylamino)con-5-enine
Con-5-enine, 3β- (dimethylamino)-
NERIINE
Con-5-enine, 3-β-(dimethylamino)-
1-Deazaadenosine
5-CONENIN-3BETA-DIMETHYLAMINE
Biological Activity
[Description]:
[Related Catalog]:
[Target]
H3 Receptor:5.4 nM (Ki)
rat H3 receptor:25 nM (Ki)
Guinea pig H3 Receptor:6.0 nM (Ki)
Dog H3 Receptor:5.7 nM (Ki)
[References]
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
450.4±45.0 °C at 760 mmHg
[ Melting Point ]:
126-127ºC
[ Molecular Formula ]:
C24H40N2
[ Molecular Weight ]:
356.588
[ Flash Point ]:
199.6±16.5 °C
[ Exact Mass ]:
356.319153
[ PSA ]:
6.48000
[ LogP ]:
5.71
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.564
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GK7621000
- CHEMICAL NAME :
- Con-5-enine, 3-beta-(dimethylamino)-
- CAS REGISTRY NUMBER :
- 546-06-5
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C24-H40-N2
- MOLECULAR WEIGHT :
- 356.66
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 208 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,373,1936
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 138 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,373,1936
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
36/37/38
[ Safety Phrases ]:
26
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
GK7621000
Articles
Minerva Med. 43(59-60) , 129-33, (1952)
Highly enantioselective construction of fused pyrrolidine systems that contain a quaternary stereocenter: concise formal synthesis of (+)-conessine.
Angew. Chem. Int. Ed. Engl. 43(19) , 2543-6, (2004)
High-performance thin layer chromatography method for estimation of conessine in herbal extract and pharmaceutical dosage formulations.
J. Pharm. Biomed. Anal. 46(2) , 391-4, (2008)
A new, simple, sensitive, precise and robust high-performance thin layer chromatographic (HPTLC) method was developed for the estimation of conessine in herbal extracts and pharmaceutical dosage forms...