12S-HETE

Names

[ Name ]:
12S-HETE

[Synonym ]:
5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, (5Z,8Z,10E,12S,14Z)-
MFCD00036916
12-HETE
(5Z,8Z,10E,12S,14Z)-12-Hydroxy-5,8,10,14-icosatetraenoic acid
12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid
12(S)-HETE

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
487.7±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₂O₃

[ Molecular Weight ]:
320.466

[ Flash Point ]:
262.8±25.2 °C

[ Exact Mass ]:
320.235138

[ PSA ]:
57.53000

[ LogP ]:
5.45

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.514

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ Hazard Codes ]:
F,Xi

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
S7-S16-S26-S36

[ RIDADR ]:
UN 1170 3/PG 2

[ HS Code ]:
2918199090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid.

Br. J. Dermatol. 172(2) , 337-44, (2015)

Pro- and anti-inflammatory metabolites of arachidonic acid - eicosanoids - participate in skin homeostasis, affecting the growth and differentiation of keratinocytes. Alterations of 12-lipoxygenase (L...

Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening.

J. Neurosci. 35(7) , 2927-41, (2015)

Axon degeneration is a programed process that takes place during development, in response to neuronal injury, and as a component of neurodegenerative disease pathology, yet the molecular mechanisms th...

MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage.

Exp. Mol. Med. 47 , e156, (2015)

Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macropha...