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Chloroacetic anhydride

Names

[ CAS No. ]:
541-88-8

[ Name ]:
Chloroacetic anhydride

[Synonym ]:
Butanoic acid, 3-chloro-4-fluoro-, methyl ester
(2-chloroacetyl) 2-chloroacetate
Chloroacetic anhydride
EINECS 208-794-2
Methyl 3-chloro-4-fluorobutanoate
MFCD00000929

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
159.0±20.0 °C at 760 mmHg

[ Melting Point ]:
51 °C

[ Molecular Formula ]:
C5H8ClFO2

[ Molecular Weight ]:
154.567

[ Flash Point ]:
63.0±10.9 °C

[ Exact Mass ]:
154.019684

[ PSA ]:
43.37000

[ LogP ]:
0.91

[ Vapour Pressure ]:
2.6±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.400

MSDS

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H314-H317

[ Precautionary Statements ]:
P280-P301 + P310-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R23/24/25;R35

[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S27

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2915900090

Synthetic Route

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Synthesis of 3,3'-bis(sulfonato)-4,4'-bis(chloroacetamido)azobenzene and cysteine cross-linking for photo-control of protein conformation and activity.

Nat. Protoc. 2(2) , 251-8, (2007)

This protocol describes a procedure for the synthesis of 3,3'-bis(sulfonato)-4,4'-bis(chloroacetamido)azobenzene (BSBCA), a water-soluble, thiol-reactive, photo-switchable cross-linker. In addition, a...

Preparation of enantiomerically pure L-7-azatryptophan by an enzymatic method and its application to the development of a fluorimetric activity assay for tryptophanyl-tRNA synthetase.

Anal. Biochem. 252(2) , 260-70, (1997)

The reaction of D,L-7-azatryptophan (D,L-7AW) with tryptophanyl-tRNA synthetase (TrpRS), adenosine triphosphate (ATP), and Mg2+ in the presence of inorganic pyrophosphatase results in the formation of...

A facile synthesis of 2-methyl-[3,4-di-O-acetyl-6-O-(chloroacetyl)-1,2-dideoxy-alpha-D-glucopyrano]-[2',1':4,5]-2-oxazoline.

Carbohydr. Res. 51(2) , 215-22, (1976)

The use of the chloroacetyl group as a protecting group has been studied for a 2-methylglyco-[2',1':4,5]-2-oxazoline. The reaction of chloroacetyl chloride or chloroacetic anhydride with 2-acetamido-1...


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Related Compounds