Benzene-1,3-diamine dihydrochloride
Names
[ CAS No. ]:
541-69-5
[ Name ]:
Benzene-1,3-diamine dihydrochloride
[Synonym ]:
1,3-Benzenediamine hydrochloride
Benzene-1,3-diamine hydrochloride (1:1)
m-Phenylene diamine hydrochloride
MFCD00012975
1,3-Benzenediamine hydrochloride (1:1)
benzene-1,3-diamine,dihydrochloride
1,3-Diaminobenzene Dihydrochloride
1,3-Benzenediamine, hydrochloride (1:1)
m-Phenylenediamine dihydrochloride
1,3-Phenylenediamine Dihydrochloride
EINECS 208-790-0
Chemical & Physical Properties
[ Boiling Point ]:
283.2ºC at 760 mmHg
[ Melting Point ]:
260°C (dec.)
[ Molecular Formula ]:
C6H9ClN2
[ Molecular Weight ]:
144.602
[ Flash Point ]:
147.6ºC
[ Exact Mass ]:
144.045425
[ PSA ]:
52.04000
[ LogP ]:
3.61740
[ Stability ]:
Stable. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
freely soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SS9800000
- CHEMICAL NAME :
- m-Phenylenediamine, dihydrochloride
- CAS REGISTRY NUMBER :
- 541-69-5
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C6-H8-N2.2Cl-H
- MOLECULAR WEIGHT :
- 181.08
- WISWESSER LINE NOTATION :
- ZR CZ &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 325 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1800 mg/kg/21W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 50 ug/plate
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,535,1985 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,111,1978
Safety Information
[ Symbol ]:
GHS06, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H311-H317-H319-H331-H341-H410
[ Precautionary Statements ]:
P261-P273-P280-P301 + P310-P305 + P351 + P338-P311
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;
[ Risk Phrases ]:
R23/24/25;R36;R43;R50/53;R68
[ Safety Phrases ]:
S28-S36/37-S45-S60-S61-S28A
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
SS9800000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
2921519090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921519090
[ Summary ]:
2921519090. o-, m-, p-phenylenediamine, diaminotoluenes, and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Infect. Immun. 77(12) , 5551-7, (2009)
It has become increasingly difficult to treat infections caused by Enterococcus faecalis due to its high levels of intrinsic and acquired antibiotic resistance. However, few studies have explored the ...
A role for nucleotides in support of breast cancer angiogenesis: heterologous receptor signalling.Br. J. Cancer 104(10) , 1628-40, (2011)
Human breast carcinoma cells secrete an adenosine 5'-diphosphate transphosphorylase (sNDPK) known to induce endothelial cell tubulogenesis in a P2Y receptor-dependent manner. We examined sNDPK secreti...
Wide cross-reactivity between Anopheles gambiae and Anopheles funestus SG6 salivary proteins supports exploitation of gSG6 as a marker of human exposure to major malaria vectors in tropical Africa.Malaria Journal 10 , 206, (2011)
The Anopheles gambiae gSG6 is an anopheline-specific salivary protein which helps female mosquitoes to efficiently feed on blood. Besides its role in haematophagy, gSG6 is immunogenic and elicits in e...