1-Hydroxy-ibuprofen

Names

[ Name ]:
1-Hydroxy-ibuprofen

[Synonym ]:
1-Hydroxy Ibuprofen
Ibuprofen Impurity L
UNII-8A1S87ZA87
1-OH-ibuprofen
1-Hydroxy Ibuprofe
1-Hydroxyibuprofen
Ibuprofen Impurity 12

Biological Activity

[Description]:

1-Hydroxy Ibuprofen is a metabolite of Ibuprofen in P. australis[1]. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[References]

[1]. Yujie He, et al. Metabolism of Ibuprofen by Phragmites australis: Uptake and Phytodegradation. Environ Sci Technol. 2017 Apr 18;51(8):4576-4584.

[2]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.

Chemical & Physical Properties

[ Melting Point ]:
80-85ºC

[ Molecular Formula ]:
C₁₃H₁₈O₃

[ Molecular Weight ]:
222.28000

[ Exact Mass ]:
222.12600

[ PSA ]:
57.53000

[ LogP ]:
2.56410

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: occurrence and environmental risk.

Sci. Total Environ. 508 , 240-50, (2015)

The occurrence of seven pharmaceuticals and two metabolites belonging to non-steroidal anti-inflammatory drugs and analgesics therapeutic classes was studied in seawaters. A total of 101 samples cover...