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Viaminate

Names

[ CAS No. ]:
53839-71-7

[ Name ]:
Viaminate

[Synonym ]:
N-(4-(Ethoxycarbonyl)phenyl)retinamide
viaminate
4-(Ethoxycarbophenyl)retinamide
4-(Carboethoxyphenyl)retinamide
retinamide ethyl benzoate
Retinamide,N-(4-(ethoxycarbonyl)phenyl)

Biological Activity

[Description]:

Viaminate is a derivative of Retinoic acid, which is used for the treatment of severe acne and other keratinization disorders.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

Viaminate is an amide compound formed by Tretinoin and Ethyl p-aminobenzoate, in which the end group of Tretinoin is transformed into amide and ester chain[1].

[References]

[1]. Zhang H, et al. Fatal Hepatotoxicity Due to Viaminate. Am J Med Sci. 2018 Jul;356(1):84-86.  

Chemical & Physical Properties

[ Density]:
1.071 g/cm3

[ Boiling Point ]:
619.4ºCat 760 mmHg

[ Melting Point ]:
177-182 °C

[ Molecular Formula ]:
C29H37NO3

[ Molecular Weight ]:
447.61

[ Flash Point ]:
328.4ºC

[ Exact Mass ]:
447.27700

[ PSA ]:
55.40000

[ LogP ]:
7.40640

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VH6409600
CHEMICAL NAME :
Retinamide, N-(4-(ethoxycarbonyl)phenyl)-
CAS REGISTRY NUMBER :
53839-71-7
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C29-H37-N-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 17,331,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8806 mg/kg/2W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 17,331,1982

Safety Information

[ Hazard Codes ]:
Xi