1H-Pyrazole-4-aceticacid, 3-(4-chlorophenyl)-1-phenyl-

Names

[ CAS No. ]:
53808-88-1

[ Name ]:
1H-Pyrazole-4-aceticacid, 3-(4-chlorophenyl)-1-phenyl-

[Synonym ]:
2-[3-(4-chlorophenyl)-1-phenylpyrazol-4-yl]acetic acid
Lonazolacum
Irritren
Lonazolaco
Lonazolac

Biological Activity

[Description]:

Lonazolac is a non-steroidal antirheumatic agent. Anti-inflammatory effects [1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Trnavský K, et al. [Lonazolac - a new non-steroidal antirheumatic agent. Report of a double-blind crossover clinical study]. Fysiatr Revmatol Vestn. 1983;61(3):147-152.

[2]. Harras MF, et al. Discovery of new non-acidic lonazolac analogues with COX-2 selectivity as potent anti-inflammatory agents. Medchemcomm. 2019;10(10):1775-1788. Published 2019 Jul 22.

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Boiling Point ]:
525.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₁₃ClN₂O₂

[ Molecular Weight ]:
312.75000

[ Flash Point ]:
271.4ºC

[ Exact Mass ]:
312.06700

[ PSA ]:
55.12000

[ LogP ]:
3.81980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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