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STX-681

Names

[ CAS No. ]:
537674-89-8

[ Name ]:
STX-681

Biological Activity

[Description]:

A novel potent, orally active, dual-acting aromatase and steroid sulfatase (STS) inhibitor with ICI0 of 0.82 nM and 39 nM, respectively; significantly reduces plasma E2 levels, completely inhibits the growth of both MCF-7(STS) tumor growth and MCF-7(AROM) tumor in a xenograft nude mouse model.

[References]

References 1. Foster PA, et al. Clin Cancer Res. 2008 Oct 15;14(20):6469-77. 2. Woo LW, et al. J Med Chem. 2007 Jul 26;50(15):3540-60. View Related Products by Target Steroid Sulfatase (STS)

Chemical & Physical Properties

[ Molecular Formula ]:
C16H13BrN6O3S

[ Molecular Weight ]:
449.283


Related Compounds