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N-(2-Aminophenyl)-N'-phenylheptanediamide

Names

[ CAS No. ]:
537034-15-4

[ Name ]:
N-(2-Aminophenyl)-N'-phenylheptanediamide

[Synonym ]:
IN1468
Histone Deacetylase Inhibitor IV
NKL 22
N-(2-Aminophenyl)-N'-phenylheptanediamide
HDAC inhibitor IV

Biological Activity

[Description]:

NKL 22 is a HDAC inhibitor. The value of IC 50 is 78 uM NKL 22 increase frataxin protein concentrationsNKL 22 inhibitors increase FXN mRNA in FRDA lymphocytes.HDAC inhibitors act directly on FXN. [1]

[Related Catalog]:

Research Areas >> Cancer

[Target]

HDAC:78 μM (IC50, in HeLa nuclear)


[References]

[1]. D Herman et al. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol, 2006 Oct, 2(10):551-8.


[Related Small Molecules]

Trichostatin A | Entinostat (MS-275) | Romidepsin (FK228, Depsipeptide) | Mocetinostat(MGCD0103) | Ricolinostat (ACY-1215) | Sodium butyrate | RGFP 966 | Quisinostat | Tubacin | DL-Sulforaphane | CUDC-907 | LMK 235 | CI-994 | Tubastatin A | Sodium phenylbutyrate

Chemical & Physical Properties

[ Density]:
1.213g/cm3

[ Boiling Point ]:
627.86ºC at 760 mmHg

[ Molecular Formula ]:
C19H23N3O2

[ Molecular Weight ]:
325.40500

[ Flash Point ]:
333.518ºC

[ Exact Mass ]:
325.17900

[ PSA ]:
91.20000

[ LogP ]:
5.67670

[ Appearance of Characters ]:
white solid

[ Index of Refraction ]:
1.644

[ Storage condition ]:
-20℃

Related Compounds

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