vindesine
Names
[ CAS No. ]:
53643-48-4
[ Name ]:
vindesine
[Synonym ]:
2H-3,7-Methanoazacycloundecino[5,4-b]indole-9-carboxylic acid, 9-[(2β,3β,4β,5α,12β,19α)-3-(aminocarbonyl)-6,7-didehydro-3,4-dihydroxy-16-methoxy-1-methylaspidospermidin-15-yl]-5-et hyl-1,4,5,6,7,8,9,14b-octahydro-5-hydroxy-, methyl ester, (5S,7S,9S)-
Vindesin
EINECS 258-682-2
methyl (5S,7S,9S)-9-[(2β,3β,4β,5α,12β,19α)-3-(aminocarbonyl)-3,4-dihydroxy-1-methyl-16-(methyloxy)-6,7-didehydroaspidospermidin-15-yl]-5-ethyl-5-hydroxy-1,4,5,6,7,8,9,14b-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indole-9-carboxylate
Vindesinum
4-Desacetylleurosidin-C-3-carboxamid
Vindesina
Methyl (13S,15S,17S)-13-[(2β,3β,4β,5α,12β,19α)-3-carbamoyl-3,4-dihydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidin-15-yl]-17-ethyl-17-hydroxy-1,11-diazatetracyclo[13.3.1.0.0]nonadeca-5,7,9,11-tetraene-13-carboxylate
Desacetylvinblastine amide
Eldesine
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Melting Point ]:
230-232ºC
[ Molecular Formula ]:
C43H55N5O7
[ Molecular Weight ]:
753.926
[ Exact Mass ]:
753.410156
[ PSA ]:
164.82000
[ LogP ]:
2.94
[ Index of Refraction ]:
1.708
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YY8080000
- CHEMICAL NAME :
- Vincaleukoblastine, 3-(aminocarbonyl)-O(sup 4)-deacetyl-3-de(methoxycarbonyl)-
- CAS REGISTRY NUMBER :
- 53643-48-4
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C43-H55-N5-O7
- MOLECULAR WEIGHT :
- 754.03
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13800 ug/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA
- TEST SYSTEM :
- Rodent - hamster
- DOSE/DURATION :
- 1100 ug/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 174,11,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7287 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 14 (estimated) No. of Female Employees: 14 (estimated)
Safety Information
[ RIDADR ]:
UN 1544
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)